Uncontrolled neural stem cell proliferation affects larval survival during dietary nutrient withdrawal.

Regulated stem cell proliferation during development is critical to produce and organize all the types required in adult organism. In some developing organisms that experience intermittent periods of starvation, physiology adapts dynamically, presumably ensure optimal development. Drosophila brain, there are two populations neuroblasts (neural cells) respond differently dietary nutrient starvation: one subtype sensitive systemic levels ceases dividing, while other continues divide regardless availability. Previous work has shown this behavior mediated by a cell-intrinsic genetic program involving Eyeless myc transcription factors. We set out understand whether arrest neuroblast plays role larval survival starvation. forced brain continue proliferate withdrawal overexpressing measured over time. Larvae with abnormal enforced died at faster rate than control larvae, suggesting for Our results consistent idea which their involved reallocating nutrients persistently dividing form nervous system sparing.